Database : HANSEN Search on : VACINAS BACTERIANAS [Subject descriptor] References found : 39 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

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Id: 13872 Author: Convit, Jacinto; Monzón, H; Pinardi, M. E; Aránzazu, N; Ulrich, M Title: The development of an active vaccine against leprosy ..- Source: s.l; s.n; 1979. 3 p. . Abstract: The development of an effective vaccine against leprosy will be directed to obtain a product which can modify the immunological response of the population susceptible to develop the disease and to avoid the occurence of lepromatous, infecting forms. This action would interrupt the transmission chain, producing a important decrease in tge incidence of the disease. The measures used at present fotr anti-leprosy campaigns such as early diagnosis, control of contacts, out-patient treatment and prevention of disabilities, can be effective if applied with a high degree of efficiency and during extended periods of time. If to these measures we could add a vaccine, we would be able to reduce considerably the expense and time needes for keeping the disease under control. The development of a vaccine against leprosy is based on the assumption the disease is due to an immunological defect of the host which is specific against this particular bacterium. Previous work done by us, where we have obtained highly favorable immunological modifications in pre-lepromatous, indeterminate patients and in Mitsuda negative contacts and, partially, in lepromatous patients, using an injection of a mixture of armadillo M. leprae and BCG, serves as basis for our proposal of using this same type of preparation as an anti-leprosy vaccine in susceptible persons, where ity would evoke a positive immunological change which would prevent the onset of infecting forms of the disease.(AU). Descriptors: VACINAS BACTERIANAS/admin HANSENIASE/imunol HANSENIASE/prev MYCOBACTERIUM LEPRAE/imunol VENEZUELA Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00575/s

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Id: 13735 Author: Ngamying, Maeya; Sawanpanyalert, Pathom; Butraporn, Raywadee; Nikasri, Junjira; Cho, Sang-Nae; Levy, Louis; Brennan, Patrick J Title: Effect of vaccination with refined components of the organism on infection of mice with Mycobacterium leprae ..- Source: s.l; s.n; 2003. 3 p. tab. Abstract: Only native products of Mycobacterium leprae, whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton-the mycolyl-arabinogalactan-peptidoglycan complex-devoid of proteins is not protective. (AU). Descriptors: HANSENIASE/prev VACINAS BACTERIANAS/imunol ESQUELETO DA PAREDE CELULAR/imunol CAMUNDONGOS ENDOGÂMICOS BALB C MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol VACINACAO Limits: ANIMAL FEMININO CAMUNDONGOS SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 13474 Author: Shepard, Charles C; Van Landingham, Rosalind M; Walker, Laura L; Ye, Shang-Zhang Title: Comparison of the immunogenicity of vaccines prepared from viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, and a mixture of the two for normal and M. leprae-tolerant mice ..- Source: s.l; s.n; jun. 1983. 8 p. graf. Abstract: Intradermal vaccines consisting of viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, or mixtures of the two were titrated in mice in doses of 10(5.2), 10(5.8), 10(6.4), 10(7.0), and 10(7.6) acid-fast bacilli. The immune response was measured by sensitization (48 to 72 h foot pad enlargement on challenge with 10(7.0) heat-killed M. leprae) and by protection against infection with a viable M. leprae challenge. There was increasing response with increasing dose of vaccine, and overall the responses to the three vaccines were similar. At the lowest dose, however, the combination of BCG and M. leprae gave superior protection. The local reaction to the vaccines in the lower dose range was less severe with the M. leprae vaccine. In another experiment, the three vaccines were compared in normal mice and in mice that had been rendered tolerant by intravenous injection of M. leprae. The tolerant mice developed no measurable sensitization on vaccination with M. leprae, but they developed partial but distinct sensitization on vaccination with BCG, alone or in combination with M. leprae. The tolerant mice developed little or no protection with any of the vaccines, however..(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol HANSENIASE/imunol TOLERÂNCIA IMUNOLOGICA VACINACAO RELACAO DOSE-RESPOSTA IMUNOLOGICA VACINAS BACTERIANAS/imunol VACINA BCG/imunol Limits: ESTUDO COMPARATIVO ANIMAL FEMININO CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01555/s

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Id: 13456 Author: Shepard, Charles C; Walker, Laura L; Van Landingham, Rosalind Title: Heat stability of Mycobacterium leprae immunogenicity ..- Source: s.l; s.n; oct. 1978. 7 p. tab, graf. Abstract: The protection provided to mice by vaccines administered intradermally was measured after footpad challenge with Mycobacterium leprae. The protection offered by M. leprae suspensions was not decreased when the vaccines were killed by 60 degrees C heat or at the higher temperatures tested, which included 215 degrees C (autoclave). Even highly purified suspensions retained their immunogenicity. In contrast, the vaccine protection provided by intradermal M. bovis (strain BCG) was markedly reduced when heated to 60 degrees C. The enlargement of the lymph nodes regional to the intradermal vaccines was measured and found generally to parallel the vaccine protection provided by M. leprae and by BCG.(AU). Descriptors: MYCOBACTERIUM BOVIS HANSENIASE/imunol MYCOBACTERIUM LEPRAE/imunol INJECOES SUBCUTÂNEAS INJECOES INTRADERMICAS VACINA BCG IMUNIDADE CELULAR VACINAS BACTERIANAS/admin VACINAS BACTERIANAS/imunol VACINAS BACTERIANAS/normas - CONGELAMENTO  CALOR Limits: ANIMAL CAMUNDONGOS SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 00293/s

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Id: 13380 Author: Shepard, Charles C; van Landingham, Rosalind; Walker, Laura L Title: Searches among mycobacterial cultures for antileprosy vaccines ..- Source: s.l; s.n; sep. 1980. 6 p. tab, graf. Abstract: All mycobacteria species share some antigens, so there may be cultivable mycobacterial cultures that can provide vaccine protection against leprosy. Vaccine protection against Mycobacterium leprae infections in mice has been demonstrated for M. leprae itself, as living or heat-killed suspensions, and for Mycobacterium bovis (BCG), as living suspensions. Results are reported here with 17 other cultures. The mycobacterial suspensions were injected intradermally, and the mice were challenged in the footpad with infectious suspensions of M. leprae. In two experiments the mice were also challenged by footpad injections of 10(7) heat-killed M. leprae so the footpad enlargment could be measured. That some mycobacterial suspensions were immunogenic for some of their own antigens was suggested by reactions at the vaccine site and enlargement of the regional lymph nodes. Some mycobacterial suspensions also stimulated footpad enlargement on challenge by homologous suspensions or by challenge with M. leprae suspensions. Consistent protection against infectious challenge with M. leprae was observed only with BCG and M. leprae, however...(AU). Descriptors: MYCOBACTERIUM/imunol MYCOBACTERIUM BOVIS/imunol LINFONODOS/imunol HANSENIASE/prev MYCOBACTERIUM LEPRAE/imunol VACINAS BACTERIANAS/uso terap VACINA BCG/uso terap Limits: ANIMAL FEMININO CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01536/s

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Id: 13309 Author: Bhide, M. B; Dholam, S. B; Chatterjee, B. R Title: Inhibition of foot pad multiplication of M. leprae in mice vaccinated with leproma derived M. leprae precursor coccoid organism and passive transfer of DTH response to normal mice through infusion of splenic cells of such vaccinated mice ..- Source: s.l; s.n; oct. 1981. 8 p. graf. Abstract: Inhibition of foot pad multiplication of M. leprae in mice vaccinated with leproma derived M. leprae precursor coccoid organism and passive transfer of DTH response to normal mice through infusion of splenic cells of such vaccinated mice.(AU). Descriptors: VACINAS BACTERIANAS/imunol HIPERSENSIBILIDADE TARDIA/imunol IMUNIZACAO PASSIVA MYCOBACTERIUM LEPRAE/imunol BACO/transpl VACINACAO Limits: ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00813/s

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Id: 12310 Author: Truoc, Le Van; Ly, Ho Minh; Thuy, Nguyen Kim; Trach, Dang Duc; Stanford, C. A; Stanford, J. L Title: Vaccination against leprosy at Ben San Leprosy Center, Ho Chi Minh City, Vietnam ..- Source: s.l; s.n; 2001. 8 p. tab. Descriptors: ADOLESCENCIA VACINA BCG VACINAS BACTERIANAS PRÉ-ESCOLAR ESQUEMA DE IMUNIZAÇAO HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM TESTES CUTANEOS FATORES DE TEMPO VACINAS DE PRODUTOS INATIVADOS VIETNA Location: BR191.1; 08663/s

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Id: 12232 Author: Oliveira, Martha M; Charlab, Rosane; Pessolani, Maria Cristina V Title: Mycobacterium bovis BCG but not mycobacterium leprae induces TNF-alpha secretion in human monocytic THP-1 cells ..- Source: Rio de Janeiro; s.n; Oct. 2001. 6 p. tab, graf. Descriptors: VACINA BCG VACINAS BACTERIANAS BOVINOS HANSENIASE MONOCITOS MONOCITOS MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE FATOR DE NECROSE TUMORAL/BI/*SE CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 08634/s

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Id: 11615 Author: Truoc, Le Van; Ly, Ho Minh; Thuy, Nguyen Kim; Trach, Dang Duc; Stanford, C. A; Stanford, J. L Title: Vaccination against leprosy at Ben San Leprosy Centre, Ho Chi Minh City, Vietnam ..- Source: s.l; s.n; 2001. 8 p. tab. Descriptors: MYCOBACTERIUM VACINA BCG VACINAS BACTERIANAS ESQUEMA DE IMUNIZAÇAO TESTES CUTANEOS FATORES DE TEMPO VACINAS DE PRODUTOS INATIVADOS VIETNA Location: BR191.1; 08438/s

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Id: 11594 Author: Martin, E; Roche, P. W; Triccas, J. A; Britton, W. J Title: DNA encoding a single mycobacterial antigen protects against leprosy infection ..- Source: s.l; s.n; 2001. 6 p. tab. Descriptors: ANTIGENOS DE BACTÉRIAS VACINA BCG VACINAS BACTERIANAS VACINAS BACTERIANAS VACINAS BACTERIANAS SEQUENCIA DE BASES PRIMERS DO DNA DNA BACTERIANO DNA BACTERIANO INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE LINFOCITOS T VACINAS DE DNA/GE/IM/*PD Limits: ANIMAL Location: BR191.1; 08417/s

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Id: 11322 Author: Naito, Mariko; Matsuoka, Masanori; Ohara, Naoya; Nomaguchi, Hiroko; Yamada, Takeshi Title: The antigen 85 complex vaccine against experimental mycobacterium leprae infection in mice ..- Source: s.l; s.n; 2000. 4 p. tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS VACINAS BACTERIANAS INTERFERON TIPO II HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM LEPRAE BAÇO BAÇO CAMUNDONGOS NUS Limits: ANIMAL Location: BR191.1; 07261/s

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Id: 11290 Author: Nath, Indira Title: A vaccine for leprosy ..- Source: s.l; s.n; 1998. 3 p. ilus, tab. Descriptors: VACINAS BACTERIANAS ENSAIOS CLINICOS REAÇOES CRUZADAS INDIA HANSENIASE MYCOBACTERIUM VACINAÇAO Location: BR191.1; 07229/s

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Id: 11034 Author: Yadava, Anjali; Mukherjee, Rama Title: An immunodominant 30-kDa antigen of a candidate anti-leprosy vaccine, mycobacterium w, shares T and B cell determinants with m. leprae and m. tuberculosis ..- Source: s.l; s.n; 1993. 11 p. ilus, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINFOCITOS B VACINAS BACTERIANAS COBAIAS HIPERSENSIBILIDADE TARDIA PESO MOLECULAR LINFOCITOS T Location: BR191.1; 07213/s

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Id: 11033 Author: Kaufmann, Stefan H. E; Young, Douglas B Title: Vaccination against tuberculosis and leprosy ..- Source: s.l; s.n; 1992. 22 p. . Descriptors: HANSENIASE ANTIGENOS DE BACTÉRIAS VACINAS BACTERIANAS IMUNIDADE CELULAR MYCOBACTERIUM TUBERCULOSE Location: BR191.1; 07211/s

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Id: 11028 Author: Talwar, G. P Title: An Immunotherapeutic vaccine for multibacillary leprosy ..- Source: s.l; s.n; 1999. 21 p. ilus, graf. Descriptors: VACINA BCG VACINAS BACTERIANAS VACINAS BACTERIANAS ENSAIOS CLINICOS HANSENIASE MYCOBACTERIUM LEPRAE TUBERCULOSE Limits: ANIMAL Location: BR191.1; 07460/s

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Id: 11023 Author: Mukhopadhyay, Asok; Panda, Amulya K; Pandey, Anil K Title: Leprosy vaccine: influence of dissolved oxygen levels on growth of a candidate strain (mycobacterium w), and storage stability of the vaccine ..- Source: s.l; s.n; 1998. 5 p. tab, graf. Descriptors: VACINAS BACTERIANAS VACINAS BACTERIANAS TÉCNICAS BACTERIOLOGICAS CATALASE ESTABILIDADE DE MEDICAMENTOS ARMAZENAGEM DE MEDICAMENTOS HANSENIASE MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM CONSUMO DE OXIGENIO SUPEROXIDO DISMUTASE BIORREATORES Location: BR191.1; 07280/s

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Id: 10331 Author: Jayaraman, K. S Title: Charges fly over rival lleprosy vaccines ..- Source: s.l; s.n; 1994. 1 p. ilus. Descriptors: VACINAS BACTERIANAS ENSAIOS CLINICOS INDIA HANSENIASE HANSENIASE MYCOBACTERIUM MYCOBACTERIUM Location: BR191.1; 07182/s

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Id: 10237 Author: Zaheer, S. Ahmed; Mukherjee, Rama; Ramkumar, Beena; Misra, Radhey S; Sharma, Amar K; Kar, Hemant K; Kaur, Harvinder; Nair, Sreekumaran; Mukherjee, Ashok; Talwar, Gursaran P Title: Combined multidrug and mycobacterium w vaccine therapy in patients with multibacillary leprosy ..- Source: s.l; s.n; 1993. 10 p. ilus, tab, graf. Descriptors: VACINAS BACTERIANAS QUIMIOTERAPIA COMBINADA SEGUIMENTOS IMUNOTERAPIA ATIVA LEPROSTATICOS HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MICOBACTERIOSE ATIPICA PELE RESULTADO DE TRATAMENTO Location: BR191.1; 06938/s

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Id: 10231 Author: Gunby, Phil Title: Can leprosy be neutralized by year 2000? ..- Source: s.l; s.n; 1992. 1 p. . Descriptors: VACINAS BACTERIANAS HANSENIASE MYCOBACTERIUM LEPRAE OFLOXACINA PREVALENCIA RIFAMPINA SAUDE MUNDIAL Location: BR191.1; 06932/s

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